Gene information
Official symbol FLT4
Official full name fms related receptor tyrosine kinase 4
Gene type protein-coding gene
Chromosome5q35.3
Alias symbolVEGFR3; PCL; VEGFR-3
Gene familyReceptor tyrosine kinases; I-set domain containing
Resources
Entrez Gene 2324
HGNC HGNC:3767
Ensembl ENSG00000037280
Vega OTTHUMG00000130931
UCSC uc003mlz.4
GO terms: 50 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001938 positive regulation of endothelial cell proliferation GO Biological Processes -32.0012114 45 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0001945 lymph vessel development GO Biological Processes -3.24032130 4 More
GO:0002040 sprouting angiogenesis GO Biological Processes -8.76593708 16 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0010575 positive regulation of vascular endothelial growth factor production GO Biological Processes -10.362168 13 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010595 positive regulation of endothelial cell migration GO Biological Processes -28.3201829 45 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0019199 transmembrane receptor protein kinase activity GO Molecular Functions -5.31743835 14 More
GO:0019902 phosphatase binding GO Molecular Functions -2.86314983 18 More
GO:0019903 protein phosphatase binding GO Molecular Functions -3.28869574 16 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030323 respiratory tube development GO Biological Processes -8.11012280 27 More
GO:0030324 lung development GO Biological Processes -8.32855168 27 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034103 regulation of tissue remodeling GO Biological Processes -21.5631413 32 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035924 cellular response to vascular endothelial growth factor stimulus GO Biological Processes -8.07167727 14 More
GO:0038084 vascular endothelial growth factor signaling pathway GO Biological Processes -6.53278734 9 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0046328 regulation of JNK cascade GO Biological Processes -6.26985667 21 More
GO:0048286 lung alveolus development GO Biological Processes -3.35916365 8 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0060312 regulation of blood vessel remodeling GO Biological Processes -5.39331932 6 More
GO:0060541 respiratory system development GO Biological Processes -8.30305934 29 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 6 records
KEGG Description Category LogP Number of genes Detail
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05224 Breast cancer KEGG Pathway -6.01672252 21 More
Drug-Gene interaction
view
Related drugs: 83 records
Drug name Interaction type Source PMID View
4sc-203 inhibitor ChemblInteractions view
ag-13958 inhibitor ChemblInteractions view
alsterpaullone DTC view
anlotinib inhibitor ChemblInteractions view
axitinib inhibitor TALCMyCancerGenomeTdgClinicalTrialChemblInteractionsCancerCommonsMyCancerGenomeClinicalTrial 18541897 view
azakenpaullone DTC view
azd-1152-hqpa DTC view
bms-690514 inhibitor ChemblInteractions view
brivanib inhibitor ChemblInteractions view
brivanib alaninate inhibitor ChemblInteractions view
cediranib inhibitor TALCDTCTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractions view
cenisertib DTC view
cep-11981 inhibitor ChemblInteractions view
cep-5214 inhibitor DTCChemblInteractions 14640546 view
cep-7055 inhibitor ChemblInteractions view
chiauranib inhibitor ChemblInteractions view
chlorpyramin hydrochloride DTC 19610651 view
cp-459632 inhibitor ChemblInteractions view
doramapimod DTC view
dovitinib inhibitor DTCTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractions view
enmd-2076 inhibitor MyCancerGenomeTdgClinicalTrial view
entrectinib DTC view
erlotinib DTC view
famitinib inhibitor ChemblInteractionsTTD view
foretinib inhibitor MyCancerGenomeChemblInteractions view
fruquintinib inhibitor TdgClinicalTrialChemblInteractionsTTD view
gefitinib DTC view
glesatinib inhibitor TALCMyCancerGenomeTdgClinicalTrial view
go-6976 DTC view
gsk-269962a DTC view
gw441756x DTC view
gw843682x DTC view
ilorasertib inhibitor DTCChemblInteractions view
imc-3c5 TdgClinicalTrialTTD 22515444 view
jnj-26483327 inhibitor ChemblInteractionsTTD view
kenpaullone DTC view
krn-633 inhibitor ChemblInteractions view
l-21649 inhibitor ChemblInteractions view
lenvatinib inhibitor TALCMyCancerGenomeTdgClinicalTrial 17943726 view
lenvatinib mesylate inhibitor ChemblInteractions view
linifanib inhibitor DTCMyCancerGenomeTdgClinicalTrialChemblInteractionsTTD view
lucitanib inhibitor ChemblInteractionsMyCancerGenomeClinicalTrial view
mgcd-265 inhibitor ChemblInteractions view
mk-2461 inhibitor TTD view
mln-8054 DTC view
motesanib inhibitor TALCMyCancerGenomeTdgClinicalTrialChemblInteractions view
muparfostat TdgClinicalTrialTTD view
nintedanib inhibitor TALCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrial 1855952431016670 view
nintedanib esylate inhibitor ChemblInteractions view
orantinib inhibitor MyCancerGenome view
osi-632 DTC view
osi-930 inhibitor ChemblInteractions view
pazopanib inhibitor TALCMyCancerGenomeTdgClinicalTrialCIViCMyCancerGenomeClinicalTrial 271602282837748417288876 view
pazopanib hydrochloride inhibitor ChemblInteractions view
pegpleranib sodium TdgClinicalTrial view
pf-00562271 DTC view
rabeprazole sodium inhibitor MyCancerGenomeTTD view
regorafenib inhibitor TALCMyCancerGenomeChemblInteractionsMyCancerGenomeClinicalTrial view
rg-1530 inhibitor ChemblInteractions view
sb-203580 DTC view
sb-220025 DTC view
semaxanib inhibitor ChemblInteractions view
sorafenib inhibitorantagonist TALCDTCTdgClinicalTrialTENDMyCancerGenomeClinicalTrialPharmGKB 161335321672990617296815164748531675735528362716 view
sorafenib tosylate inhibitor ChemblInteractions view
sotrastaurin DTC view
sp-600125 DTC view
su-014813 inhibitor ChemblInteractions view
sunitinib inhibitor TALCTdgClinicalTrialTENDMyCancerGenomeClinicalTrialPharmGKB 15688612176058141729681522015057192489711736776316685460 view
sunitinib malate inhibitor ChemblInteractions view
surufatinib inhibitor ChemblInteractionsTTD view
tae-684 DTC view
tak-593 inhibitor ChemblInteractions view
tak-715 DTC view
tandutinib DTC view
telatinib inhibitor TALCMyCancerGenomeTdgClinicalTrialChemblInteractions view
tesevatinib inhibitor MyCancerGenomeTdgClinicalTrial view
tivozanib inhibitor TALCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractionsTTD view
tozasertib DTC view
vandetanib inhibitor TALCTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractionsMyCancerGenomeClinicalTrial view
vatalanib inhibitor DTCMyCancerGenomeTdgClinicalTrialChemblInteractionsTTD 17584317 view
x-82 inhibitor MyCancerGenomeChemblInteractions view
xl-820 inhibitor ChemblInteractions view
xl-999 inhibitor ChemblInteractions view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
Chr5:180664473 hypermethylation epigenomics ischemic cardiac events[prognosis (bad)] myocardial infarction Thunders M et al. Epigenetics. 2019
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